Cell Fate Specification: Cytoplasmic Determinants.
Because cell fate determination requires the expressions of lineage-specific transcription factors, the enforced expression of lineage-specific transcription factors was extensively used to induce cell fate conversion. In pursuing hepatic transdifferentiation, the key issue is to find an appropriate combination of hepatic transcription factors.
The potency of the cell decreases, meaning it loses the ability to become anything and eventually becomes determined, or establishes an irreversible fate if left alone. This cell is fated to become.
Cell Fate Determination Process by which cellular differentiation occurs, during which a cell's phenotypic potential becomes increasingly narrowed while functionality becomes increasingly enhanced.
CELL DETERMINATION is the process by which portions of the genome are selected for expression in different embryonic cells. This involves developmental decisions that gradually restrict cell fate. Cells can progress from TOTIPOTENT to PLURIPOTENT to DETERMINED. Note the importance of EXTRINSIC versus INTRINSIC factors.
Cell fate commitment is achieved by the establishment of cell type-specific transcriptional programs, which in turn are guided, reinforced, and ultimately locked-in by epigenetic mechanisms.
The fate of a cell describes what it will become in the course of normal development. The developmental potential, or potency, of a cell describes the range of different cell types it CAN become. The determination of different cell types (cell fates) involves progressive restrictions in their developmental potentials.
During early development in Drosophila, the spatial information of maternal gradients is translated into discrete transcriptional states determining cell fate. Information transfer depends on reproducibility of the gradients themselves, as well as the ability of cells to accurately measure and utilize morphogen concentrations in biologically meaning ways.
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The simplest fate decision is a binary decision, when a cell chooses between one of only two possible fates. Binary fate decisions feature prominently in neural development, largely because the inherently binary process of cell division is used to couple neural proliferation and differentiation.
With this data, he was able to construct a fate map, which is a diagram that shows the developmental fate of various cells from an early-stage embryo. Improving Fate Mapping Techniques.
Faith is something different to everyone. If you asked a hundred different people, it is possible that you would get many diverse answers. Religious faith and non-religious faith are two very distinct terms. Faith holds an extremely complex meaning when discussing it in the context of religion. Faith is a belief.
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The nervous system represents the most complex organ of C. elegans.It is the organ with the most cells (302 neurons and 56 glial cells make up 37% of the somatic cells in a hermaphrodite) and the largest cellular diversity (at least 118 different neuron classes).
